A compartment‐specific transcriptome analysis reveals survival‐relevant marker genes in the stroma fraction of squamous non‐small cell lung cancer
Identifieur interne : 001E70 ( Main/Exploration ); précédent : 001E69; suivant : 001E71A compartment‐specific transcriptome analysis reveals survival‐relevant marker genes in the stroma fraction of squamous non‐small cell lung cancer
Auteurs : Klaus Bendrat [Allemagne] ; Axel Stang [Allemagne] ; Georgi Georgiev [Allemagne] ; Robert Geffers [Allemagne] ; Bernd Haase [Allemagne] ; Karin Schütze [Allemagne] ; Dimitar Mogilarov [Allemagne] ; Detlev Branscheid [Allemagne] ; Axel Niendorf [Allemagne]Source :
- Journal of Biophotonics [ 1864-063X ] ; 2012-04.
English descriptors
- Teeft :
- Adeno carcinoma, Affymetrix, Agilent technologies, Antigen presentation, Axel niendorf, Axel stang, Bendrat, Biophotonics, Carcinoma, Cell lung cancer, Clin, Clin cancer, Clinical outcome, Detlev branscheid, Different survival groups, Early stage, Early stage nsclc patients, Epithelium, Expression ratios, Full article, Gene, Gene activity, Gene expression, Gene expression changes, Gene symbols, Genome biol, Georgi georgiev, Gmbh, Good prognosis, Good prognosis group, Hamburg, Hamburg dataset, High expression, High numbers, Higher expression, Histological subtypes, Immune, Immune response, Immunological memory, Immunosuppressive foxp3, Invariant chain, Keratin, Kgaa, Large cell carcinoma, Large cell neuroendocrine carcinoma, Lnec, Long survival, Lower half, Lung cancer, Median gene expression, Microdissected, Microdissected sccs, Molecular biology, Months survival time, Nsclc, Nsclc samples, Nsclc subtypes, Nsclc vaccines, Online, Online color, Permutation, Possible role, Practical reasons, Probe sets, Probe sets form, Prognosis, Prognosis group, Prognostic, Prognostic impact, Prognostic relevance, Protein detection, Pure tumor, Recent studies, Resected, Resected nsclc patients, Samples microdissected, Short survival, Squamous, Squamous cell carcinoma, Squamous cell carcinomas, Squamous cell lung cancer, Squamous cell lung cancer klaus bendrat, Squamous nsclc, Staining cases, Stroma, Stroma compartment, Stroma fractions, Stroma genes, Stroma preparations, Stromal, Stromal factors, Strong tumor gene, Study design, Subtype bias, Subtypes, Survival data, Survival genes, Survival groups, Survival markers, Survival plot, Survival probe sets, Thorac oncol, Threshold value, Transcriptome, Transcriptome analysis, Tumor, Tumor biology, Tumor cells, Tumor parenchyma, Tumor samples, Tumor stages, Tumor stroma, Typical stroma genes, Verlag, Verlag gmbh, Weinheim, Weinheim figure, Weinheim journal.
Abstract
Although it is increasingly recognized that the tumor biology is influenced by the tumor stroma, prognostic gene signatures are usually derived from tissue consisting of tumor cells and surrounding stroma. This study presents a compartment‐specific transcriptome analysis of lung squamous cell carcinoma (SCC) samples microdissected into tumor parenchyma and stroma fractions. Typical tumor and stroma genes were identified based on the expression ratios between the two compartments. Our results indicate that in SCC many markers related to longer survival are predominantly expressed in the stroma, particularly genes of the MHC‐II complex. Stromal upregulation of MHC‐II genes seems crucial for a clinically relevant antitumor immune response in SCC. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Url:
DOI: 10.1002/jbio.201100115
Affiliations:
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This study presents a compartment‐specific transcriptome analysis of lung squamous cell carcinoma (SCC) samples microdissected into tumor parenchyma and stroma fractions. Typical tumor and stroma genes were identified based on the expression ratios between the two compartments. Our results indicate that in SCC many markers related to longer survival are predominantly expressed in the stroma, particularly genes of the MHC‐II complex. Stromal upregulation of MHC‐II genes seems crucial for a clinically relevant antitumor immune response in SCC. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Hambourg</li></region><settlement><li>Hambourg</li></settlement></list><tree><country name="Allemagne"><region name="Hambourg"><name sortKey="Bendrat, Klaus" sort="Bendrat, Klaus" uniqKey="Bendrat K" first="Klaus" last="Bendrat">Klaus Bendrat</name></region><name sortKey="Bendrat, Klaus" sort="Bendrat, Klaus" uniqKey="Bendrat K" first="Klaus" last="Bendrat">Klaus Bendrat</name><name sortKey="Bendrat, Klaus" sort="Bendrat, Klaus" uniqKey="Bendrat K" first="Klaus" last="Bendrat">Klaus Bendrat</name><name sortKey="Bendrat, Klaus" sort="Bendrat, Klaus" uniqKey="Bendrat K" first="Klaus" last="Bendrat">Klaus Bendrat</name><name sortKey="Branscheid, Detlev" sort="Branscheid, Detlev" uniqKey="Branscheid D" first="Detlev" last="Branscheid">Detlev Branscheid</name><name sortKey="Branscheid, Detlev" sort="Branscheid, Detlev" uniqKey="Branscheid D" first="Detlev" last="Branscheid">Detlev Branscheid</name><name sortKey="Geffers, Robert" sort="Geffers, Robert" uniqKey="Geffers R" first="Robert" last="Geffers">Robert Geffers</name><name sortKey="Georgiev, Georgi" sort="Georgiev, Georgi" uniqKey="Georgiev G" first="Georgi" last="Georgiev">Georgi Georgiev</name><name sortKey="Haase, Bernd" sort="Haase, Bernd" uniqKey="Haase B" first="Bernd" last="Haase">Bernd Haase</name><name sortKey="Mogilarov, Dimitar" sort="Mogilarov, Dimitar" uniqKey="Mogilarov D" first="Dimitar" last="Mogilarov">Dimitar Mogilarov</name><name sortKey="Niendorf, Axel" sort="Niendorf, Axel" uniqKey="Niendorf A" first="Axel" last="Niendorf">Axel Niendorf</name><name sortKey="Schutze, Karin" sort="Schutze, Karin" uniqKey="Schutze K" first="Karin" last="Schütze">Karin Schütze</name><name sortKey="Stang, Axel" sort="Stang, Axel" uniqKey="Stang A" first="Axel" last="Stang">Axel Stang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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